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Vasoconstriction of NPY induced by DPP-4i can similarly elevate BP via a Ca 2+ -dependent vasoconstrictive effect, thus suggesting that the combination of DPP-4i and Ca 2+ antagonists can improve the situation

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The experimental data from rats suggest that the inhibitory effect of GLP-1 on gastric motor function is mediated by the afferent vagal nerve, through interaction with GLP-1Rs located in vagal afferent fibers that transmit sensory signals to the brain (161)

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